Effect of Frequency of Uniform and Disturbed Pulsatility Flow on Tissue Factor Expression of Human Umbilical Vein Endothelial Cells
نویسندگان
چکیده
Numerous studies demonstrate that atherosclerotic lesion development occurs at the site of the blood vessel that is subjected to disturbed flow [1-3], such as the lesser curve of the aortic arch or at bifurcations. These observations have led researchers to hypothesize that different types of blood flow have different effects on the function of endothelial cells (ECs) that line the blood vessels and are directly exposed to hemodynamic forces. The major mechanical force is fluid shear stress, the frictional force on ECs generated by blood flow. Disturbed flow occurs when the fluid shear stress is not constant in magnitude or frequency.
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